Blackbox Bio

The Machine Learning Box

A unified platform for in vivo behavioral research: automated, high-throughput rodent behavior screening, from capture to objective readouts.

Instruments

Two instruments. One standard.

Blackbox One

The Standard for In Vivo Behavior

Our original rodent imaging instrument for high-fidelity, streamlined data acquisition. Capture body video and paw print data for a single mouse or rat, or run four animals at once with the optional 4-chamber setup.

  • 30 × 30 cm open field
  • Optional 4-chamber setup
  • Up to 4 units per workstation
New

Blackbox Two

The Most Advanced In Vivo Platform Ever Created

Totally redesigned to enable a range of new capabilities. Everything in Blackbox One, plus a larger recording area with improved sensitivity and an available 3D Module with four additional lateral cameras.

  • 40 × 40 cm recording area
  • 3D Module: 5 simultaneous views
  • Facial expression & 3D kinematics
  1. 1

    Roam freely, in the dark

    Rodents move naturally inside an opaque black chamber in apparent darkness, recorded from below with a near-infrared (NIR)-enhanced HD machine vision camera.

  2. 2

    Capture pose and paw contact

    Body pose is captured with a rapid pulse of NIR light, while plantar contact area and weight distribution of each paw are recorded separately by our proprietary sensor.

  3. 3

    Score behavior automatically

    The data streams combine into a high-speed, high-resolution video ethogram, so behaviors are scored automatically, with high sensitivity.

Software

palmreader™

Capture, analyze, and visualize every recording in one app

Palmreader™ runs on your Blackbox workstation and turns each recording into structured behavioral data. Palmreader Ethos scores behaviors frame by frame, while posture, weight-bearing, and gait analyses measure how the body moves, all from the same session. Built-in graphs then let you explore and compare your groups.

  • Posture, weight bearing, gait, and automated behavior scoring from a single analysis
  • Built-in statistics and interactive graphs to compare groups
  • Fast analysis and compact data files that are easy to share

Analysis

1 Recording4 Analysis Modules

Every session yields posture, weight bearing, gait, and behavior data, with no extra animals and no extra runs.

01

Postural Analysis

  • Pose estimation
  • Body part distances
  • Joint angles
  • Toe spread
Read the docs
02

Dynamic Weight-Bearing Analysis

  • Left vs. right
  • Forepaws vs. hindpaws
  • Paw area
Read the docs
03

Gait Analysis

  • Stride length & step width
  • Duty factors
  • Spatial & temporal symmetry
  • Velocity
Read the docs
04

Automated Behavioral Scoring

  • Grooming
  • Licking & scratching
  • Rearing
  • Locomotion
Read the docs

Scientific Applications

Objective endpoints, across research areas

Pain & Somatosensory Research

Quantify pain states and sensory dysfunction with objective endpoints.

  • Neuropathic Pain
  • Inflammatory Pain
  • CIPN
  • Chronic Pain
  • Gait
  • Weight Bearing
  • Posture
  • Behavior

Orthopedics & Musculoskeletal

Assess injury and recovery across musculoskeletal models.

  • Fracture
  • Osteoarthritis
  • Tendon & Ligament Injury
  • Muscle Injury
  • Gait
  • Weight Bearing
  • Posture
  • Activity

Spinal Cord & Neural Injury

Measure functional impairment and recovery after neural injury.

  • Spinal Cord Injury
  • Peripheral Nerve Injury
  • Axon Regeneration
  • Functional Recovery
  • Gait
  • Weight Bearing
  • Posture
  • Behavior

Itch & Sensory Behavior

Automatically detect and quantify itch-related and other sensory behaviors.

  • Acute Itch
  • Chronic Itch
  • Scratching
  • Grooming
  • Behavior
  • Scratching
  • Grooming
  • Posture

Therapeutic Efficacy & Drug Discovery

Measure treatment response and optimize drug candidates.

  • Analgesia
  • Dose Response
  • Functional Recovery
  • Efficacy vs. Sedation
  • Efficacy
  • Dose Response
  • Recovery
  • Behavior

Safety, Toxicology & Tolerability

Identify and quantify adverse effects and treatment tolerability.

  • Nausea
  • Sedation
  • Motor Impairment
  • Tremor
  • Adverse Behavioral Effects
  • Behavior
  • Activity
  • Gait
  • Posture

Neuromuscular Disease

Evaluate motor function and disease progression in neuromuscular models.

  • SMA
  • Muscular Dystrophy
  • Neuropathy
  • Muscle Weakness
  • Gait
  • Posture
  • Strength
  • Activity
Coming Q1 2027

Neurodegeneration & Motor Function

Characterize motor deficits and disease progression in neurodegenerative models.

  • Parkinson's
  • Huntington's
  • ALS
  • Tremor
  • Gait
  • Posture
  • Tremor
  • Activity
Coming Q1 2027

Cognition & Social Behavior

Investigate cognitive functions and social interactions.

  • Social Interaction
  • Exploration
  • Memory & Cognition
  • Novel Object Recognition
  • Social Interaction
  • Exploration
  • Memory
  • Behavior

Trusted Worldwide

Labs using the Blackbox™ platform

Users across academia, government, and pharma rely on Blackbox.

  • University of Zurich
  • Ulm University
  • University of South Carolina
  • Orion Pharma
  • Rush University
  • Cleveland Clinic
  • Myologica
  • Medical College of Wisconsin
  • Department of Veterans Affairs
  • Brixton Bio
  • Columbia University
  • Ohio State University
  • University of Copenhagen
  • University of Oulu
  • University of California Los Angeles
  • University of Michigan
  • University of Sydney
  • Xyzagen
  • University of Minnesota
  • Harvard Department of Stem Cell and Regenerative Biology
  • Michigan State University
  • Queen's University
  • Salk Institute for Biological Studies
  • Department of Defense
  • Brigham and Women's Hospital
  • Boston Children's Hospital
  • University of Texas at Dallas
  • UT Southwestern Medical School
  • University of Texas Medical Branch
  • Rutgers
  • St. Vincent's University Hospital Elm Park
  • McGill University
  • University of New England
  • Penn State
  • University of Louisville
  • University of Toronto
  • National Institutes of Health
  • University of Helsinki
  • Massachusetts General Hospital
  • Université Clermont Auvergne
  • Boston University
  • Tafalgie
  • University of California San Francisco

Interested in learning more?

We are transforming rodent behavior screening by partnering with researchers to deliver automated, high-throughput behavioral analysis that enables deeper insights and more reproducible results. Contact us to learn how Blackbox can support your lab.

Heatmap of a mouse paw print showing weight distribution